Polymorphisms of nicotinic acetylcholine receptors in Alzheimer’s disease: a systematic review and data analysis

Abstract Objective This study was conducted to accomplish a better insight into the impact of single nucleotide polymorphisms (SNPs) nicotinic acetylcholine receptors (nAChR) at risk Alzheimer’s disease (AD) and their possible pathogenicity. Methods We carried out systemic review accessible studies. The case–control studies were assessed by an electronic search international local databases identify relevant on SNPs relating nAChR genes in AD. Two reviewers evaluated inclusion/exclusion criteria, summarized, analyzed extracted data. used odds ratios (ORs) with 95% confidence intervals (CIs) for reporting our Online checked pathogenicity statistically significant SNPs. Also, online databases, including NCBI, NIH, ClinVar, RegulomeDB, Ensemble, analyze structure function, DNA features, flank sequencing Results Among all collected SNPs, rs4779978 rs1827294 CHRNA7, rs1044394 CHRNA4, rs1127314 CHRNB2 showed between AD cases controls. Conclusions Some from reviewed reports show evidence supporting involvement pathology. However, more comprehensive are necessary exact correlation role disease.